Epidermal growth factor receptor (EGFR) is a molecule that sits on the surface of healthy cells, including lung cells, transmitting signals that tell the cell what to do—for example, whether or not it should grow. A mutation, or defect, in the molecule can cause it to transmit too many signals, which may make the cell grow out of control.
There are different processes that can cause a cell to become cancerous. The results of the biomarker tests can help doctors to identify what is causing the problem, as this information can help determine a treatment plan. This is generally accomplished by testing a sample of the tumor.
Patients with untreated, advanced (metastatic), non-small cell lung cancers (NSCLCs) that test positive for certain EGFR mutations may be eligible to be treated with GILOTRIF.