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What is non-small cell lung cancer (NSCLC)?

Normal cells multiply when the body needs them, and die when the body doesn’t. Cancer occurs when cells grow out of control, multiply to form lumps (called tumors), and disrupt how organs function. Lung cancers sometimes originate from the cells that line the tubes inside your lungs, but can advance and spread to the area around the lungs, as well as other places in the body. Non-small cell lung cancer or NSCLC gets its name from the type of cells involved.

Sometimes, NSCLC may involve epidermal growth factor receptor (or EGFR), a molecule that sits on the surface of lung cells. In some people, mutations (or genetic defects) occur in EGFR that cause them to send out signals that begin to make cancer cells grow out of control, and spread to other parts of your body.

WHAT IS GILOTRIF?

GILOTRIF is a prescription medicine that is used to treat people with non-small cell lung cancer (NSCLC) that:

• has certain (non-resistant) abnormal epidermal growth factor receptor (EGFR) gene(s). Your healthcare provider will perform a test to make sure that GILOTRIF is right for you.

• has spread to other parts of the body (metastatic), and

• has not been previously treated for metastatic lung cancer

It is not known if GILOTRIF is safe and effective in treating people with lung cancer that has resistant abnormal EGFR genes.

or

is used to treat people with squamous cell lung cancer that:

• has spread to other parts of the body, and

• has been previously treated with chemotherapy that contains platinum.


It is not known if GILOTRIF is safe and effective in children.