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What is non-small cell lung cancer (NSCLC)?

Normal cells multiply when the body needs them, and die when the body doesn’t. Cancer occurs when cells grow out of control, multiply to form lumps (called tumors), and disrupt how organs function. Lung cancers sometimes originate from the cells that line the tubes inside your lungs, but can advance and spread to the area around the lungs, as well as other places in the body. Non-small cell lung cancer or NSCLC gets its name from the type of cells involved.

Sometimes, NSCLC may involve epidermal growth factor receptor (or EGFR), a molecule that sits on the surface of lung cells. In some people, mutations (or genetic defects) occur in EGFR that cause them to send out signals that begin to make cancer cells grow out of control, and spread to other parts of your body.


GILOTRIF is a prescription medicine used to treat people with non-small cell lung cancer (NSCLC):

• that has certain types of abnormal epidermal growth factor receptor (EGFR) genes. Your doctor will perform a test to check for certain types of abnormal EGFR genes, and make sure that GILOTRIF is right for you. GILOTRIF may be used when you have not had previous treatment for cancer that has spread to other parts of the body. It is not known if GILOTRIF is safe and effective in treating lung cancer with other abnormal EGFR genes.


• that is squamous type and has spread to other parts of the body after you have tried chemotherapy that contains platinum.

It is not known if GILOTRIF is safe and effective in children.